Mesquite has enjoyed a great turnaround season under first-year head coach DeMarcus Harris.
After a 2-7 campaign a year ago, the Skeeters not only put together a winning season, they returned to the playoffs for the first time in two years and notched a postseason victory to go with it after their 42-19 win over Sachse in the bi-district round.
But Friday introduced an entirely different challenge in the form of state title contender Duncanville, and the Panthers showed exactly why they are one of the top-ranked teams in the state as they rolled to a 52-2 victory in a Class 6A Division I area round playoff game at Ford Stadium.
The Panthers (10-1) advance to take on Spring in the regional semifinals, while Mesquite finishes the season with a 7-5 record.
Duncanville struck first on a short touchdown run by Jordan Crook and Malachi Medlock followed with a pair of 1-yard scoring runs to open a 20-0 lead.
Medlock was not finished in the first half, as Medlock broke free for a 57-yard touchdown run and Solomon James hooked up with Dakorien Moore on a 48-yard scoring strike to make it 33-0 at the break.
The Panthers went back to work in the third quarter, with Omari Abor scoring from eight yards out.
The Skeeters were able to make a big special teams play, blocking the extra point attempt, with Josh Williams scooping up the loose ball and returning it 83 yards for the two points.
But that would not be enough to shift the momentum of the night.
The Duncanville defense got into the act, with Donovan McFail intercepting a pass and returning it 61 yards to paydirt, and Jaiden Jones tacked on a 6-yard touchdown run to provide the final 52-2 margin.